Organization

Field Name

ID

Required

KCR

EGFR Mutational Analysis

34128

yes 

SEER

EGFR Mutational Analysis

3939

yes 

Note 1 This SSDI is effective for diagnosis years 2021+

  • For cases diagnosed 2018-2020, leave this SSDI blank

Note 2 Physician statement of EGFR can be used to code this data item when no other information is available.

Note 3 EGFR may be recorded for all histologies and stages; however, it is primarily performed for advanced non-small cell carcinomas. If information is not available, code 9.

Note 4 The most common EGFR mutations are

  • Exon 18 Gly719
  • Exon 19 deletion
  • Exon 20 insertion
  • Exon 20 Thr790Met
  • Exon 21 Leu858Arg

Note 5 If EGFR is positive and there is no mention of the mutated codon, or the mutated codon is not specified, code 4.

Note 6 If neoadjuvant therapy is given, record the assay from tumor specimens prior to neoadjuvant therapy.

  • If neoadjuvant therapy is given and there are no EGFR results from pre-treatment specimens, report the findings from post-treatment specimens

Note 7 Code 9 when

  • Insufficient amount of tissue available to perform test
  • No microscopic confirmation of tumor
  • EGFR not ordered or not done, or unknown if ordered or done

Code

Description

0

Normal
EGFR negative, EGFR wild type
Negative for mutations, no alterations, no mutations (somatic) identified, not present, not detected

1

Abnormal (mutated)/detected in exon(s) 18, 19, 20, and/or 21

2

Abnormal (mutated)/detected but not in exon(s) 18, 19, 20, and/or 21

4

Abnormal (mutated)/detected, NOS, exon(s) not specified

7

Test ordered, results not in chart

8

Not applicable: Information not collected for this case
(If this information is required by your standard setter, use of code 8 may result in an edit error.)

9

Not documented in medical record
EGFR not assessed or unknown if assessed

<BLANK>

N/A - Diagnosis year is prior to 2021