Grade Post Therapy Path (yp) (Corpus Sarcoma)

Note 1 Leave Grade Post Therapy Path (yp) blank when

• No neoadjuvant therapy
• Clinical or pathological case only
• Neoadjuvant therapy completed; surgical resection not done
• There is only one grade available and it cannot be determined if it is clinical, pathological, post therapy clinical or post therapy pathological

Note 2 There is a preferred grading system for this schema. If the post therapy clinical grade given uses the preferred grading system and the post therapy pathological grade does not use the preferred grading system, do not record the Grade Post Therapy Clin (yc) in the Grade Post Therapy Path (yp) field. Assign Grade Post Therapy Path (yp) 9.

• Example Neoadjuvant therapy completed. Biopsy of corpus shows a well differentiated endometrioid carcinoma, FIGO Grade 1. The surgical resection states a high grade endometrioid carcinoma
• Code Grade Post Therapy Clin (yc) as 1 since FIGO and well differentiated is the preferred grading system
• Code Grade Post Therapy Path (yp) as 9 since the preferred grading system was not used and the Generic Grade Categories do not apply to this grade table

Note 3 Assign the highest grade from the resected primary tumor assessed after the completion of neoadjuvant therapy.

• Per clarification from the CAP Cancer Committee based on the CAP Protocol, the following histologies must be assigned a G3 (code 3) Serous, clear cell, undifferentiated/de-differentiated carcinomas, carcinosarcomas, and mixed mesodermal tumors (Mullerian/MMMT) are high risk (high grade)

Note 4 If there are multiple tumors with different grades abstracted as one primary, code the highest grade.

Note 5 G3 includes anaplastic.

Note 6 Use the grade from the post therapy clinical work up from the primary tumor in different scenarios based on behavior or surgical resection

• Behavior
• Tumor behavior for the post therapy clinical and the post therapy pathological diagnoses are the same AND the post therapy clinical grade is the highest grade
• Tumor behavior for post therapy clinical diagnosis is invasive, and the tumor behavior for the post therapy pathological diagnosis is in situ
• Surgical Resection
• Surgical resection is done of the primary tumor after neoadjuvant therapy is completed and there is no grade documented from the surgical resection
• Surgical resection is done of the primary tumor after neoadjuvant therapy is completed and there is no residual cancer

Note 7 Code 9 (unknown) when

• Surgical resection is done after neoadjuvant therapy and grade from the primary site is not documented
• Surgical resection is done after neoadjuvant therapy and there is no residual cancer
• Grade checked "not applicable" on CAP Protocol (if available) and no other grade information is available