Organization | Field Name | ID | Required |
|---|---|---|---|
KCR | Brain Molecular Markers | 34013 | yes |
SEER | Brain Molecular Markers | 3816 | yes |
Note 1: This data item was introduced in 2018 and applied to the following ICD-O-3 histology codes 9400/3, 9401/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3
- These are codes 01-09 and are applicable for cases diagnosed 2018+ and are in ICD-O-3 order
Note 2: In 2022, the 5th edition of the CNS WHO Blue Book was released and the following histologies were added 9385/3, 9396/3, 9421/1, 9430/3, 9500/3
- These are codes 10-23 and are applicable for cases diagnosed 2024+ and are in ICD-O-3 order
Note 3: If a microscopically confirmed histology is not included in this list, assign, code 85.
- If your case is not microscopically confirmed, code 99
Note 4: Physician statement of histologic subtype can be used to code this data item.
Note 5: See Brain Molecular Markers in the SSDI Manual, in the Definition section for more information on the different histologies.
Examples:
- Biopsy of brain tumor, microscopic confirmation diagnosis: Diffuse Astrocytoma (9400/3). Additional testing done, and IDH-mutant is identified. Code 01.
- Biopsy of brain tumor, microscopic confirmation diagnosis: Anaplastic astrocytoma (9401/3). No further testing or results unknown. Code 99.
- MRI of brain tumor, clinical diagnosis: glioblastoma. No further workup. Code 99.
- Biopsy of brain tumor, microscopic confirmation diagnosis: Mixed glioma (9382/3). Code 85.
| Code | ICD-O-3 Code | ICD-O-Description |
|---|---|---|
| 01 | 9400/3 | Astrocytoma, IDH-mutant, grade 2 |
| 02 | 9400/3 | Diffuse astrocytoma, IDH-wildtype |
| 03 | 9401/3 | Astrocytoma, IDH-mutant, grade 3 |
| 04 | 9401/3 | Anaplastic astrocytoma, IDH-wildtype |
| 05 | 9440/3 | Glioblastoma, IDH-wildtype |
| 06 | 9450/3 | Oligodendroglioma, IDH-mutant and 1 p/19q co-deleted |
| 07 | 9451/3 | Oligodendroglioma, IDH-mutant and 1p/19q co-deleted, grade 3 |
| 08 | 9471/3 | Medulloblastoma, SHH-activated and TP53-wildtype |
| 09 | 9478/3 | Embryonal tumor with multilayered rosettes, C19MC-altered |
| 10 | 9385/3 | Diffuse hemispheric glioma, H3-34 mutant (new for 2024+) |
| 11 | 9385/3 | Diffuse midline glioma, H3 K27-altered (new for 2024+) |
| 12 | 9385/3 | Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (new for 2024+) |
| 13 | 9385/3 | Infant-type hemispheric glioma (new for 2024+) |
| 14 | 9396/3 | Posterior fossa group A (PFA) ependymoma (new for 2024+) |
| 15 | 9396/3 | Posterior fossa group B (PFB) ependymoma (new for 2024+) |
| 16 | 9396/3 | Spinal ependymoma, MYCN-amplified (new for 2024+) |
| 17 | 9396/3 | Supratentorial ependymoma, YAP1 fusion-positive (new for 2024+) |
| 18 | 9396/3 | Supratentorial ependymoma, ZFTA fusion-positive (new for 2024+) |
| 19 | 9421/1 | Diffuse astrocytoma, MYB- or MYBL1-altered (new for 2024+) |
| 20 | 9421/1 | Diffuse low-grade glioma, MAPK pathway-altered (new for 2024+) |
| 21 | 9430/3 | Astroblastoma, MN1-altered (new for 2024+) |
| 22 | 9500/3 | CNS neuroblastoma, FOXR2-activated (new for 2024+) |
| 23 | 9500/3 | CNS tumor BCOR internal tandem duplication (new for 2024+) |
| 85 | NA | Not applicable: Histology not 9385/3, 9396/3, 9400/3, 9401/3, 9430/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3, 9421/1, 9430/3, 9500/3 |
| 86 | NA | Benign or borderline tumor |
| 87 | NA | Test ordered, results not in chart |
| 88 | NA | Not applicable: Information not collected for this case |
| 99 | NA | Not documented in medical record |
Codes before 2024
Code | Description |
|---|---|
01 | Diffuse astrocytoma, IDH-mutant (9400/3) |
02 | Diffuse astrocytoma, IDH-wildtype (9400/3) |
03 | Anaplastic astrocytoma, IDH-mutant (9401/3) |
04 | Anaplastic astrocytoma, IDH-wildtype (9401/3) |
05 | Glioblastoma, IDH-wildtype (9440/3) |
06 | Oligodendroglioma, IDH-mutant and 1 p/19q co-deleted (9450/3) |
07 | Anaplastic oligodendroglioma, IDH-mutant and 1p/19q co-deleted (9451/3) |
08 | Medulloblastoma, SHH-activated and TP53-wildtype (9471/3) |
09 | Embryonal tumor with multilayered rosettes, C19MC-altered (9478/3) |
85 | Not applicable: Histology not 9400/3, 9401/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3 |
86 | Benign or borderline tumor |
87 | Test ordered, results not in chart |
88 | Not applicable: Information not collected for this case |
99 | Not documented in medical record |
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