Notes (reportable for cases diagnosed 1/1/2024 & forward)

Note 1: There is evidence that human papilloma virus (HPV) plays a role in the pathogenesis of some cancers. HPV testing may be performed for prognostic purposes; testing may also be performed on metastatic sites to aid in determination of the primary site.

Note 2: Record the results of any HPV testing performed on pathological specimens including surgical and cytological (from cell blocks) tissue from the primary tumor or a metastatic site, including lymph nodes. Do not record the results of blood tests or serology.

Note 3: There are several methods for the determination of HPV status. The most frequently used test is IHC for p16 expression which is surrogate marker for HPV infection. Do not record the results of IHC p16 expression in this field. The rest of the tests (based on ISH, PCR, RT-PCR technologies) detect the viral DNA or RNA. This data item is only for HPV status determined by tests designed to detect viral DNA or RNA.

Note 4: HPV-type 16 refers to virus type and is different from p16 overexpression (p16+).

Note 5: Codes 0-7 are hierarchical; use the highest code that applies.

CodeDescription
10

HPV negative by p16 test

11

HPV positive by p16 test

20

HPV negative for viral DNA by ISH test

21

HPV positive for viral DNA by ISH test

30

HPV negative for viral DNA by PCR test

31

HPV positive for viral DNA by PCR test

40

HPV negative by ISH E6/E7 RNA test

41

HPV positive by ISH E6/E7 RNA test

50

HPV negative by RT-PCR E6/E7 RNA test

51

HPV positive by RT-PCR E6/E7 RNA test

70

HPV status reported in medical records as negative, but test type is unknown

71

HPV status reported in medical records as positive, but test type is unknown

97

Test done, results not in chart

99

Not documented in medical record
HPV test not done, not assessed, or unknown if assessed

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