Page History

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The current Solid Tumor Rules, the Hematopoietic and Lymphoid Neoplasm Coding Manual and Database, and the International Classification of Diseases for Oncology, Third Edition, Second Revision Morphology (ICD-O-3.2) are the standard references for histology codes.

See the NAACCR website for additional updates for 2023.

Histology Coding for Solid Tumors

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Refer to the most current Solid Tumor Rules for histology code changes.

1. Beginning with cases diagnosed 01/01/2022

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, p16 test results can be used to code squamous cell carcinoma, HPV positive (8085) and squamous cell carcinoma, HPV negative (8086).

2. Beginning

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with cases diagnosed 01/01/2022, non-keratinizing squamous cell carcinoma, HPV positive is coded 8085 for sites listed in Head and Neck Solid Tumor Rules Table 5 only. A diagnosis of non-keratinizing squamous cell carcinoma, NOS is coded 8072.

3. Beginning

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with cases diagnosed 01/01/2022, keratinizing squamous cell carcinoma, HPV negative is coded 8086 for sites listed in Head and Neck Solid Tumor Rules Table 5 only. A diagnosis of keratinizing squamous cell carcinoma, NOS is coded 8071.

4. Clear cell papillary renal cell carcinoma is coded 8323/3. The 2016 WHO Classification of Tumors of the Urinary System and Male Genital Organs, 4th Edition,

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reclassified this histology as a /1 because it is low nuclear grade and is now thought to be a neoplasia. This change has not yet been implemented and it remains reportable as behavior /3.

Site-specific histology coding rules cover the following sites/types.

Histology Coding for Hematopoietic and Lymphatic Primaries

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