Page History
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The current Solid Tumor Rules, the Hematopoietic and Lymphoid Neoplasm Coding Manual and Database, and the International Classification of Diseases for Oncology, Third Edition, Second Revision Morphology (ICD-O-3.2) are the standard references for histology codes.
See the NAACCR website for additional updates for 2023.
Histology Coding for Solid Tumors
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Refer to the most current Solid Tumor Rules for histology code changes.
1. Beginning with cases diagnosed 01/01/2022
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, p16 test results can be used to code squamous cell carcinoma, HPV positive (8085) and squamous cell carcinoma, HPV negative (8086).
2. Beginning
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with cases diagnosed 01/01/2022, non-keratinizing squamous cell carcinoma, HPV positive is coded 8085 for sites listed in Head and Neck Solid Tumor Rules Table 5 only. A diagnosis of non-keratinizing squamous cell carcinoma, NOS is coded 8072.
3. Beginning
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with cases diagnosed 01/01/2022, keratinizing squamous cell carcinoma, HPV negative is coded 8086 for sites listed in Head and Neck Solid Tumor Rules Table 5 only. A diagnosis of keratinizing squamous cell carcinoma, NOS is coded 8071.
4. Clear cell papillary renal cell carcinoma is coded 8323/3. The 2016 WHO Classification of Tumors of the Urinary System and Male Genital Organs, 4th Edition,
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reclassified this histology as a /1 because it is low nuclear grade and is now thought to be a neoplasia. This change has not yet been implemented and it remains reportable as behavior /3.
Site-specific histology coding rules cover the following sites/types.
Primary Site | Topography |
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Head and Neck | C000-C148, C300-C329, C410, C411, C442 |
Colon, Rectosigmoid, Rectum | C180-C189, C199, C209 |
Lung | C340-C349 |
Cutaneous Melanoma | C440-C449 with Histology 8720-8780 |
Breast | C500-C506, C508-C509 |
Kidney | C649 |
Urinary Sites | C659, C669, C670-C679, C680-C681, C688-C689 |
Non-malignant CNS | C700, C701, C709, C710-C719, C720-C725, C728, C729, C751-C753 |
Malignant CNS and Peripheral Nerves | C470-C479, C700, C701, C709, C710-C719, C720-C725, C728, C729, C751-C753 |
Other Sites | Excludes Head and Neck, Colon, Rectosigmoid, Rectum, Lung, Cutaneous Melanoma, Breast, Kidney, Urinary Sites, Peripheral Nerves, CNS |
Histology Coding for Hematopoietic and Lymphatic Primaries
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